Dynamic, mechanistic models of biology
Our Systems modeling services help derive mechanistic, translational insights from mathematical models of biological processes at the subcellular levels.
The modeling and simulations can be used for the following:
- Disease models: Mechanism of action, virtual knock-in/knock-out simulations, phenotypes
- Toxicity Assessment: Simulate the time and dose-dependent effect of a drug to establish the safety window; Heptox platform for hepatoxicity
- PK/PD models: Establish dose-concentration-response relationships and simulate time-effect courses; determine in vivo efficacy and first-in-human dose
- Clinical Study design: Compartmental/non-compartmental models, adaptive trial design
- Bioprocess simulations: Manufacturing process simulations, scale-up and real-time optimization of operating conditions
Effect of a protease inhibitor on bilirubin levels in normal and Gilbert’s syndrome patients
